Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine

Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine

Le Tourneau, Christophe; Kamal, Maud

Springer International Publishing AG

10/2016

144

Mole

Inglês

9783319371764

15 a 20 dias

The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice.
Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials.- Basis for Molecular Genetics in Cancer.- Microarrays Based Molecular Profiling to Identify Genomic Alterations.- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential.- Bioinformatics for Precision Medicine in Oncology.- Assessment of Biomarkers' Predictive Value of Efficacy.- Designs for Evaluating Precision Medicine Trials.- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.
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